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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EEF2K All Species: 24.85
Human Site: S500 Identified Species: 54.67
UniProt: O00418 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00418 NP_037434.1 725 82144 S500 R L H L P R A S A V A L E V Q
Chimpanzee Pan troglodytes XP_001161085 725 82249 S500 R L H L P R A S A V A L E V Q
Rhesus Macaque Macaca mulatta XP_001092565 725 82310 S500 R L H L P R A S A V A L E V Q
Dog Lupus familis XP_536939 725 81954 S500 R L H L S R P S A V A L E V Q
Cat Felis silvestris
Mouse Mus musculus O08796 724 81720 S499 R L H L P R P S A V A L E V Q
Rat Rattus norvegicus P70531 724 81471 S499 R L H L P R P S A V A L E V Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508333 641 73286 K441 I G K S I L G K V H L A M V R
Chicken Gallus gallus XP_414920 725 82845 S500 R V H I H R P S C V A Q E I Q
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001002740 706 80225 A484 I H R P S C V A V E V E R L N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O01991 768 87807 L499 Q S V P A N I L S L Q L Q Q M
Sea Urchin Strong. purpuratus XP_788087 683 78401 L470 V Q L R K T M L V T S T G G S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 97.5 93 N.A. 89.9 90 N.A. 75.3 78.7 N.A. 64.6 N.A. N.A. N.A. 38.6 45.5
Protein Similarity: 100 99.5 98.7 96.6 N.A. 94.7 94.3 N.A. 81.9 89.5 N.A. 75.4 N.A. N.A. N.A. 56.3 60.6
P-Site Identity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 6.6 53.3 N.A. 0 N.A. N.A. N.A. 6.6 0
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 13.3 73.3 N.A. 13.3 N.A. N.A. N.A. 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 28 10 55 0 64 10 0 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 10 0 10 64 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 0 0 0 10 0 0 0 0 0 10 10 0 % G
% His: 0 10 64 0 10 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 19 0 0 10 10 0 10 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 10 0 10 0 0 10 0 0 0 0 0 0 0 % K
% Leu: 0 55 10 55 0 10 0 19 0 10 10 64 0 10 0 % L
% Met: 0 0 0 0 0 0 10 0 0 0 0 0 10 0 10 % M
% Asn: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 0 0 19 46 0 37 0 0 0 0 0 0 0 0 % P
% Gln: 10 10 0 0 0 0 0 0 0 0 10 10 10 10 64 % Q
% Arg: 64 0 10 10 0 64 0 0 0 0 0 0 10 0 10 % R
% Ser: 0 10 0 10 19 0 0 64 10 0 10 0 0 0 10 % S
% Thr: 0 0 0 0 0 10 0 0 0 10 0 10 0 0 0 % T
% Val: 10 10 10 0 0 0 10 0 28 64 10 0 0 64 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _